The type 2 diabetes gene
An international team of French, Canadian and Danish researchers have identified a gene "susceptible to cause type 2 diabetes and that would explain insulin resistance. A discovery that could improve the treatment of this disease.
The results of the study conducted by the team of Philippe Froguel (CNRS - University Lille 2 - Pasteur Institute of Lille, and Imperial College London), in collaboration with researchers from McGill University in Montreal (Canada) and the University of Copenhagen (Denmark) was published Sunday in the journal Nature Genetics.
Each mutation of a chromosome around the identified gene says IRS 1 (Insulin Receptor Substrate 1) increases the risk of developing type 2 diabetes by an average of 20%. The mutation of the IRS1 gene prevents insulin from regulating glucose. So far, the 30 identified diabetes-related genes have influenced insulin production. For the first time, researchers have discovered a gene that has a direct role in insulin dysfunction, insulin resistance, characteristic of obesity and pre-diabetic states.
"People with mutations associated with the IRS1 gene are resistant to insulin that is no longer effective enough to lower blood sugar," notes the CNRS in a statement that adds "it forces these people to secrete excessive amounts of insulin with serious potential consequences for the risk of cardiovascular disease and various cancers ".
The discovery of this new gene involved in the risk of developing type 2 diabetes allows researchers to work on new treatments. Today, we only know how to limit complications related to diabetes.