Genetic variations predisposing to different cancers

Genetic variations predisposing to different cancers

Genetic variations especially on chromosome 9p21 are associated with an increased risk of developing brain and skin cancers, according to five studies published Sunday in the journal Nature Genetics.

A study conducted by the MDAnderson Center (University of Texas, USA) and the London Cancer Research Institute found variations associated with an increased risk of glioma in 5 genes including the CDKN2A gene located on chromosome 9.

Gliomas are the most common brain tumors in adults.

An American study from the University of California (San Francisco) and the Mayo Clinic showed a link between variations on chromosome 9 and an aggressive form of brain cancer, glioblastoma.

"This is not a reason why individuals with these genetic variations pass a CT scan every year," however tempered Robert Jenkins, one of the authors of the study, highlighting the role of environmental factors in the development of cancers.

Genetic variations on chromosome 9p21 associated with an increased risk of melanoma, the most serious skin cancer, have also been identified in two studies, one conducted in both Europe and Australia.

Finally genetic variations, including one on chromosome 9p21, are also associated with an increased risk of basal cell carcinoma, the most common form of skin cancer, according to researchers at deCode Genetics.

The main known risk factor for skin cancer is sun exposure.

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